Wayne Rooney could face former club Manchester United in the FA Cup fifth round if Derby beat Northampton in their replay, while Chelsea will host either Liverpool or Shrewsbury.
Liverpool’s replay with Shrewsbury will also take place on February 4 and Jurgen Klopp has already promised to play “the kids” at Anfield.
If the Liverpool youngsters see off their League One opponents, they will face rivals Chelsea in a repeat of the 2012 FA Cup final.
Manchester City, who won the trophy last year with a 6-0 thrashing of Watford, will travel to Championship side Sheffield Wednesday.
Arsenal will play 2008 winners Portsmouth at Fratton Park after beating Bournemouth 2-1 on Monday night.
Tottenham or Southampton, who face a replay in north London, will host Norwich, while Leicester will host Coventry or Birmingham.
Championship leaders West Brom have been handed a home tie against the winners of Newcastle and Oxford’s replay, while Reading or Cardiff will host Sheffield United.
The fifth-round fixtures will take place in the week commencing Monday, March 2. The FA have scrapped replays should any of the fifth-round games be drawn as part of their commitment to a winter break in February for Premier League sides.
FA Cup fifth-round draw in full
Sheffield Wednesday vs Manchester City
Reading/Cardiff vs Sheffield United
Chelsea vs Shrewsbury/Liverpool
West Brom vs Newcastle/Oxford
Leicester vs Coventry/Birmingham
Northampton/Derby vs Manchester United
Southampton/Tottenham vs Norwich
Portsmouth vs Arsenal
FA Cup key dates
Replays: February 4
Fifth round: March 2-5
Quarter-final: Saturday March 21
Semi-final: Saturday April 18/19
Final: Saturday May 23
The Women fifth-round fixtures will take place in the week commencing Monday, March 2.
Women’s FA Cup fifth-round fixtures
Bristol City vs Everton
Coventry vs Tottenham
Leicester vs Reading
Southampton/Crystal Palace vs Brighton
Manchester City vs Ipswich
Arsenal vs Lewes
Sunderland vs Birmingham
Chelsea vs Liverpool